Marijuana : Is that it The most Perilous Tablet?

Take a deep breath!

In 2012, a study at the University of California, San Francisco (UCSF) calculated that even smoking just one joint every single day for 20 years may be benign, though most participants only smoked two or three joints each month. “I was surprised we didn’t see effects [of marijuana use],” said UCSF epidemiologist Mark Pletcher, who led the study.

One assessment of varied epidemiological studies points to small sample size and poor study design as reasons for scientists’inability to nail down a link between cannabis and cancer risk. But some suspect that this type of link doesn’t exist, and that marijuana could even have cancer-preventive effects. Do CBD gummies help with pain? A 2008 study, for example, suggested that smoking marijuana may reduce the chance of tobacco-associated lung cancer, calculating that people who smoke both marijuana and tobacco have a lesser threat of cancer than those who smoke only tobacco (though still an increased risk than non-smokers).

But even Pletcher isn’t sanguine about marijuana’s effects on the lungs, and suspects that there may be long-term lung damage that can be hard to detect. “We really can’t reassure ourselves about heavy use,” he explained.

Your brain on drugs

There is some evidence to suggest that stoned subjects exhibit increased risk-taking and impaired decision-making, and score worse on memory tasks-and residual impairments have been detected days or even weeks after use. Some studies also link years of regular marijuana use to deficits in memory, learning, and concentration. A recent and widely discussed report on the IQs of New Zealanders followed since birth unearthed that cannabis users who’d started their habit in adolescence had lower IQs than non-users.

In this study, led by researchers at Duke University, “you can clearly see as a consequence of cannabis use, IQ falls,” said Derik Hermann, a medical neuroscientist at the Central Institute of Mental Health in Germany who had been not involved in the research.

However, not 4 months later, a re-analysis and computer simulation at the Ragnar Frisch Center for Economic Research in Oslo countered the Duke findings. Ole Rogeberg contended that socioeconomic factors, not marijuana use, contributed to the lower IQs observed in cannabis users.

Rogeberg’s conclusion counters a large literature, however, which supports a link between pot use and neurophysiological decline. Studies in both humans and animals suggest that people who acquiring a marijuana habit in adolescence face long-term negative impacts on brain function, with some users finding it difficult to concentrate and learn new tasks.

Notably, most studies about them suggest that while there may be negative consequences of smoking as a teenager, users who begin in adulthood are usually unaffected. This may be as a result of endocannabinoid-directed reorganization of the mind during puberty, Hermann explained. The intake of cannabinoids that is included with pot use could cause irreversible “misleading of the neural growth,” he said.

As well as the results for intelligence, many studies suggest that smoking marijuana raises the chance of schizophrenia, and could have similar effects on the brain. Hermann’s group used MRI to detect cannabis-associated neuron damage in the pre-frontal cortex and found so it was much like brain changes observed in schizophrenia patients. Other studies further suggest that weed-smoking schizophrenics have greater disease-associated brain changes and perform worse on cognitive tests than their non-smoking counterparts.

But much of the research can’t distinguish between brain changes resulting from marijuana use and symptoms related to the disease. It’s possible that cannabis-smoking schizophrenics “might have unpleasant symptoms [that precede full-blown schizophrenia] and are self-medicating” with the psychotropic drug, said Roland Lamarine, a professor of community health at California State University, Chico. “We haven’t seen a rise in schizophrenics, even with much more marijuana use.”

In fact, other research shows that cannabis-using schizophrenics score better on cognitive tests than non-using schizophrenics. Such conflicting reports may be as a result of varying concentrations-and varying effects-of cannabinoids in marijuana. As well as tetrahydrocannabinol (THC), a neurotoxic cannabinoid that is accountable for marijuana’s mind-altering properties, the drug also contains a number of non-psychoactive cannabinoids, including cannabidiol (CBD), that may protect against neuron damage. Hermann unearthed that the amount of the hippocampus-a brain area important for memory processing-is slightly smaller in cannabis users than in non-users, but more CBD-rich marijuana countered this effect.

A lethal cocktail?

While data supporting the harmful ramifications of marijuana alone are weak, some researchers are more focused on the drug along with other substances, such as for example tobacco, alcohol, or cocaine. Some studies suggest, for example, that marijuana may increase cravings for other drugs, resulting in its infamous tag as a “gateway drug.” A study published earlier this month supported this theory when it unearthed that, at the least in rats, THC exposure increases tobacco’s addictive effects. Furthermore, marijuana might not mix well with prescription drugs, as cannabis causes the liver to metabolize drugs more slowly, raising the chance of drug toxicity.

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